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Loss of CNS GIPR augments weight loss with GLP-1R agonism To examine whether CNS GIPR is required for the additive weight loss effect of combination treatment with mGIPR-Ab and clinically approved GLP-1R agonists, HFD-fed Gipr fl/fl control mice and Gipr Syn/ mice received IP dosing of either vehiclevehicle, dulaglutidevehicle or dulaglutidemGIPR-Ab combination treatments

Body mass index is associated with epigenetic age acceleration in the visceral adipose tissue of subjects with severe obesity

Infarct volume analysis was performed using ImageJ (NIH, USA), with results normalized as a percentage of the contralateral hemispheres area to account for edema and tissue shrinkage

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