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Targeting Appetite Centers: Semaglutide impacts areas in the brain that regulate appetite and food intake, leading to a reduction in hunger and caloric consumption
doi: 10.21037/atm.2016.08.63
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TMAO is also a significant factor in diabetic kidney disease (DKD) progression, with elevated plasma TMAO levels leading to NLRP3 inflammasome formation and activation in endothelial cells, which then results in endothelial dysfunction, increased monocyte adhesion, and production of pro-inflammatory cytokines in blood vessels, eventually progressing to vascular oxidative stress and DKD
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