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Drugs interfering with the assembly or function of KMT2A-r fusion complexes, such as Disruptor of telomeric silencing 1-like (DOT1L) and Menin inhibitors, have also shown efficacy in preclinical models, 43 , 44 with Menin inhibitors showing promise in ongoing clinical trials ( clinicaltrials gov
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A 2012 Cochrane review of GH supplementation and exercise in healthy older adults (12 RCTs, N=220) found that GH alone increased lean mass by 2.1 kg but did not improve muscle strength
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