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Safety considerations: Nausea is the most common side effect during dose escalation

This pattern is consistent with the body reaching a steady state where even the small amount of absorbed tirzepatide no longer provides enough stimulation to overcome natural appetite regulatory mechanisms

Compared to use of a placebo (84 patients) in this trial, use of -tocopherol (85 patients) significantly slowed progression of Alzheimer's dementia, evidenced by significant improvements on the Blessed Dementia Scale and time to institutionalization (122)

Discontinuation and switching decisions belong with a treating clinician, particularly for people managing diabetes alongside weight