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Tirzepatide engages GIP near the strength of the natural hormone but activates GLP-1 about 18 times more weakly than natural GLP-1. After accounting for protein binding in blood, the drug is roughly 20-fold GIP-forward and has no meaningful glucagon activity
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Together, they synergistically promote tissue regeneration, collagen remodeling, and immune modulation in preclinical models
10.1016/j.cell.2020.05.042 44 InthavongK.MaJ.ShangY.DongJ.ChettyA
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