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It is also important to mention, that the Beta-Carotene and Retinol Efficacy Trial (CARET) tested daily intake of the combination of 30 mg beta-carotene and 25,000 IU vitamin A against placebo in 18,314 men and women
The 39 sweeteners cover all commercially used sweeteners that could be purchased as pure compounds
Let the baseline protocol establish itself
And while these trials are important to understanding the safety and efficacy of drugs, "no randomized controlled trial" is not the same as "no evidence." We have the accumulated experience of thousands of clinicians who have prescribed these compounds for nearly a decade and watched real patients get better in real time
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