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However, it is important to clearly distinguish between cosmetic peptides and prescription-only compounds such as Cagrilintide and Semaglutide , which are not skincare ingredients

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The GLP-1 agonist, exenatide, increased fasting EF via endothelial nitric oxide (NO) synthase (eNOS) activation, nitric oxide (NO) production in endothelial cells, induced dose-dependent vasorelaxation, and reduced high-glucose or lipid-induced endothelial dysfunction in arterioles ex vivo [64]

But lets keep in mind that these trials were not only funded by the maker of the medications but also had a lot of exclusion criteria