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Because GHS-R is also expressed on hypothalamic neurons regulating somatostatin tone, Ipamorelin transiently reduces somatostatin inhibition of pituitary GH release effectively releasing the somatostatin 'brake' while CJC-1295 pushes the GHRH 'accelerator'
Source: Hwang, et al JAMA Health Forum March 14, 2025 Researchers from the University of Chicago modeled the clinical and financial impact of anti-obesity medications: Zepbound (tirzepatide), Wegovy (semaglutide), and two oral generic drug combinations, phentermine-topiramate and naltrexone-bupropion
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