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They found that under laser irradiation, with its great photothermal conversion efficiency, it could generate considerable heat, causing cell death in more than 70% of HT-29 human colorectal adenocarcinoma cells (while cisplatin exerted a small anti-tumor effect)

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This modification mainly occurs at cytosine residues present in GC dinucleotide-rich regions clustered together to form the CpG islands spanned the 5end region of several genes (Issa and Kantarjian, 2009)

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