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While microdosing began as a do-it-yourself trend to help manage side effects or save money, it has been increasingly endorsed by doctors for a variety of reasons, from weight loss maintenance to enhancing longevity

That success has begun to be reflected in each company's growth: Lilly's revenue has increased significantly faster than Novo Nordisk's over the past year

This downregulation leads to the accumulation of the intermediate 3-hydroxy-lanost-8-en-32-al, a known translational repressor of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)

Further proof of concept for GLP-1 as a chronic treatment for type 2 diabetes came through a study by Zander et al