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However, the body may rely on its effects to help manage appetite and metabolism, so stopping can feel challenging
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When the elimination half-life is much shorter than the dosing interval, accumulation is negligible, and steady-state exposure approximates single-dose exposure ( The accumulation factor (R) for repeated dosing at a fixed interval can be derived from standard pharmacokinetic theory and approximated as: Where k is the elimination rate constant (k = 0.693/t) and is the dosing interval
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