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At a dose of 0.03 mg/kg, Grade II somnolence was observed in one of two subjects, leading to the recommended single dose for further Phase I studies being set at 0.025 mg/kg/day Dorr et al., 199600160-3)
13.8% in the placebo group had a primary endpoint (hazard ratio, 0.86
Shaking the hand often provides quick relief because it temporarily restores blood flow and reduces nerve pressure
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