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The Food and Drug Administration (FDA) 's Drug Trials Snapshots program, running continuously since January 2015, reports participant demographics from key clinical trials supporting CDER's original approvals of new drugs ( [1] ), yet a peer-reviewed 2025 analysis of 341 pivotal FDA trials conducted between 2017 and 2023 found that only 6% achieved enrollment aligned with the four largest US racial and ethnic groups' population shares ( [2] )

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GLP-1 receptor activation reduces appetite, slows gastric emptying, promotes insulin secretion from pancreatic beta cells, and creates the characteristic feeling of fullness that GLP-1 agonist users report