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In regions such as the African and Asian continents and the Mediterranean river basin there exists a high frequency of the different variants of the enzymatic deficiency, whereas in China and Japan the frequency is low 23

Discussion In this paper, we develop the first mathematical model of the GSH antioxidant system in the outer retina, capturing the most essential components for ROS creation, GSH production, oxidation in neutralizing ROS, and reduction as well as the diversion of glucose into the PPP to synthesize NADPH

The aim is to restore normal levels, improve energy metabolism, and protect organs such as the heart and muscles