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Its effects are systemic despite being locally administered, with preliminary trial evidence showing accelerated repair in distant injuries including tendon tears, ulcers, and damaged blood vessels
It is part of a complex internal network
Mechanistic studies would be strengthened by isoform-specific NOS experiments, FAK or paxillin pathway inhibition, VEGFR2 pathway modulation, direct measurement of endothelial and fibroblast markers, and rescue experiments that test whether blocking one pathway prevents downstream effects
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