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This conservative approach allows assessment of individual response before considering dose increases
Additionally, preclinical animal models provide mechanistic insights but may not fully translate to human physiology, particularly in conditions such as osteoporosis, obesity-related bone changes, and joint infections
Even where the agency accepts a recommendation, the substance is only added to the 503A list through formal notice-and-comment rulemaking
(BPH Registry and Patient Survey Steering Committee) (October 2007)
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