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This pathway regulates: Protein synthesis (through mTORC1 activation) Cell survival and proliferation (Akt-dependent) Glucose metabolism Mitochondrial function MAPK/ERK Pathway Activation IGF-1 LR3 also activates the mitogen-activated protein kinase (MAPK/ERK) pathway, which regulates gene transcription and cell proliferation independent of mTOR signalling
Bi S, Tu Z, Chen D, et al
Millar, N
Biochem Pharmacol 33 (12): 19291932
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