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Orforglipron is only one of several next-generation GLP-1 drugs that are expected to reach the public in the near future
A single freeze-thaw cycle reduces potency by 10-15%, and multiple cycles compound the damage
A 2021 study identified a putative beta-arrestin "superagonist" of the ghrelin receptor, showing that biased agonism at this receptor could produce functionally distinct outcomes depending on which signaling pathway is preferentially activated
Factor #3: The birth control absorption concern The theoretical problem works like this: GLP-1s slow gastric emptying by 60-70%, while oral contraceptive pills need to move from stomach to small intestine to be absorbed
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