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To exclude artifactual alterations by the FITC group, we performed kinetic-binding experiments with unlabeled agonists, in competition with exendin-4-FITC, and defined both association rate constants and residence times 43 with consistent effects (Fig

Direct evidence of FATP2-KOinduced cellmediated glucagon-like peptide 1 (GLP-1) secretion included increased GLP-1+ cell mass in FATP2-KO db/db mice, small-molecule FATP2 inhibitor enhancement of GLP-1 secretion in TC1-6 cells and human islets, and exendin[9-39]-inhibitable insulin secretion in FATP2 inhibitortreated human islets

Both drugs demonstrate good safety for the majority of individuals