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12 The Raf-MEK- ERK mitogen activates the protein kinase pathway, which is triggered by growth factors, hormones and cytokines that regulate the proliferation, differentiation, survival, senescence, and migration of tumor cells
Melanocytes can also function as neuroendocrine cells by producing acetylcholine, catecholamines, and POMC-derived peptides, which have the capacity to mediate local immunoinflammatory and antimicrobial responses and to modulate the biological behaviour of oral tissues [4]
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