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By encapsulating polylactic acid-glycolic acid copolymer (PLGA) nanoparticles within the hybridized membrane, antigens and adjuvants from both cell membrane sources could be delivered simultaneously, thereby enhancing the innate immune response

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Unlike the endogenous ligands, which have short half-life, rapid degradation by dipeptidyl peptidase-4 (DPP-4) enzyme and undesirable side effects, such as hypoglycemia and nausea (Drucker, 2023, Nature), retatrutide has been engineered to overcome these limitations

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