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This suppression reduces production of pro-inflammatory cytokines including TNF-alpha, IL-6, and IL-1, creating an environment more conducive to tissue repair
Laboratory investigations using ionizing radiation-induced senescent cells demonstrate that FOXO4-DRI causes p53 nuclear exclusion and mitochondrial targeting, validating the proposed mechanism of selective senescent cell elimination through targeted protein-protein interaction disruption
Oncogene 25:163948, PMID: 16550164 Coles BF, Morel F, Rauch C, Huber WW, Yang M, Teitel CH, Green B, Lang NP, Kadlubar FF (2001) Effect of polymorphism in the human glutathione S -transferase A1 promoter on hepatic GSTA1 and GSTA2 expression
And any such research would be very much at the end of a long queue of far more essential and life-preserving research such as anti-cancer or anti-viral therapy
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