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These species contribute to oxidative and nitrosative stress by promoting protein nitration and nitrosation reactions, thereby affecting enzyme activity and cellular signalling pathways

Indeed, Yan et al (2020), exposed marine medaka to either MPs alone (100 g/L about 1 103 particles/mL 2.5 m fluorescent polystyrene), heavy metals (Cd 10 g/L, Pb 50 g/L, and Zn 100 g/L) or MPs and heavy metals combined (MPs 100 g/L, Cd 10 g/L, Pb 50 g/L, and Zn 100 g/L) for a month and concluded that, while all treatments changed the composition of the GM, the impact was highly dependent on the exposure-group as well as gender