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Compared with metformin and second- or third-line glucose-lowering medication groups, major adverse CVEs were significantly lower in patients with NAFLD and type 2 diabetes taking GLP-1RAs, but not different from those taking SGLT2 inhibitors
The piece investigates how drugs like Ozempic, originally for diabetes, have become status symbols and appetite suppressants among the non-diabetic elite, especially in entertainment and fashion
By pumping the accumulated, unbound cytosolic catecholamines backward across the plasma membrane and safely into the extracellular synaptic space, the neuron is able to maintain its free cytoplasmic neurotransmitter levels below toxic thresholds , directly protecting itself from oxidative cell death and preserving neuronal viability (Underhill et al., 2021)
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