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Aggregating data from Table 3 reveals consistent cross-barrier alterations in cytokine levels in both CSF and peripheral blood across different clinical stages (first-episode/FES, acute/ASZ, and chronic/CSZ), which hold clinical translational significance: 1)

Yes Akkermansia strengthens the gut barrier, increases SCFA synergy, improves GLP-1 sensitivity, and reduces inflammation

Similarly, ferrostatin-1 can restore gut microbiota homeostasis and alleviate ionizing radiation-induced intestinal injury by inhibiting ferroptosis and the p53-mediated apoptosis signaling pathway [93]