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Presented for research literature review only Ketley JN et al

Two carboxyl groups on a side chain disclosed by patent CN111378028A are naked and are not protected by a protective group, the purity of an intermediate obtained in the subsequent coupling reaction with an Arg34GLP-1 (9-37) main peptide chain is not high, only 67.5 percent is obtained, the yield is seriously reduced, and the pH value in the reaction has a large influence on the side chain modification, so that various byproducts which are difficult to remove are easily generated, such as a double-modified impurity byproduct with both the 26 th position and the end position of the main peptide chain modified and a byproduct with the end position of the main peptide chain modified

Les participants taient tous des personnes en surpoids svre ou obses (105 kg en moyenne)