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The impact of thrombin on astrocytes is dose-dependent: low concentrations promote cell survival and synaptic plasticity, whereas at high thrombin concentrations, reactive astrocytes and microglia proliferate and lose their glutamate regulatory function, leading to excitotoxicity and production of reactive oxygen species, inflammatory cytokines (IL-1 , TNF- ), and inducible NOS
Pericardial division and intrapericardial lysis of adhesions was performed as needed to expose the heart and great vessels
amid surge of extraditions"