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1 Introduction In the context of T regulatory lymphocytes, innate Treg (nTreg, or natural Treg, which leaves the thymus in the form of mature cells) and acquired Treg (iTreg, induced Treg, generated by naive CD4+ T response to antigenic stimulation) have been characterized ( 1) Modulation of APC (Antigen-presenting cell)

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[40] [41] Example 1: Preparation of 4-chloro-3-hvdroxybutyronitrile (2) [42] 185.2 g of potassium cyanide (KCN) was dissolved in 431 mL of water, and 171 mL of a 65 % sulfuric acid solution was slowly added dropwise thereto in an ice bath such that a pH value of the reaction solution was adjusted to a range of 8 to 10