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Accumulated evidence suggests that long term treatment with GLP-1 receptor agonist is associated with a reduction in measured glomerular filtration rate (GFR), preservation of renal function and/or a decrease in the incidence of cardiovascular events

In addition, for NSBSO treated B16 cells, the expression of GPX4 did not have obvious change, but the expression of GCL decreased obviously (Additional file 1: Figs

It is also contraindicated in patients with a history of acute pancreatitis and in those with a family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia type 2 syndrome

That compared to a mean reduction of 0.41 percentage points for those on the placebo