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Hesperidin supplementation also led to a 33% reduction in median levels of the inflammatory marker high-sensitivity C-reactive protein (hs-CRP), as well as significant decreases in levels of total cholesterol, apolipoprotein B (apoB), and markers of vascular inflammation, relative to placebo (Rizza 2011)
A study published in Circulation noted that while these reductions in muscle volume appear proportionate to the weight loss achieved, the concern remains that excessive lean mass loss could lead to sarcopenia, reduced metabolic rate, and poorer long-term outcomes
The 1997 amphetamine finding also resurfaced
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