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Traditional Chinese medicine or HDS (26.81%), anti-tuberculosis drugs (21.99%), and anti-tumor drugs or immunomodulators (8.34%) are the major causes of DILI in China [13]

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6 Beyond the cancer cell itself, the tumor microenvironment (TME), comprising immune cells, stromal components, and extracellular matrix, plays a pivotal role in shaping therapeutic outcomes by fostering immune evasion, altering drug availability, and facilitating cellular crosstalk that promotes resistance