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The anti-fibrotic properties extend beyond single organs
These two amino acids (U and Q) are not highly similar, but are both midrange in size, and polar in nature, because the selenol residue is predominantly ionized at physiological pH
This broad regulatory activity includes upregulation of tissue repair genes, collagen synthesis pathways, antioxidant defense systems, and anti-inflammatory signaling networks, alongside simultaneous downregulation of genes associated with tissue destruction, inflammation, and fibrosis
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