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That came out of animal model studies, where they gave large amounts of these drugs, and the animal model would get what's called C cell hyperplasia
The triple-agonist net effect adds an energy-expenditure arm to the classical incretin (energy-intake suppression) pharmacology explaining retatrutides weight-loss signal exceeding dual agonism at lower absolute dose
By helping you feel satisfied with smaller amounts of food, these injections can significantly reduce overall calorie intake
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