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In response to pathogens, oxidative stress and pro-inflammatory cytokines, such as the tumor necrosis factor (TNF)-, intestinal epithelial cells, increase the production of the chemokine interleukin-8 (IL-8), triggering an inflammatory reaction in the colonic mucosa that promotes IBD and colorectal carcinogenesis (911)

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In this regard, recent studies showed attenuation of Ang-2 induced cardiac fibrosis by alteration of AT1/AT2 receptor expression and ACE activity in rat hearts [174]