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In general, repeated cycles of weight loss and regain is associated with worsened cardiometabolic risk factors, says Sara Velayati, MD, obesity medicine specialist and assistant professor at Albert Einstein College of Medicine in New York City

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That might sound like a lot, but further study found that the constipation was transient (which means it was temporary and goes away on its own) in 99% of patients, and that it was rated as mild to moderate in 98% of patients

By striving to reconcile the disparity between its considerable neuroprotective potential and recent clinical challenges, we can enhance our understanding of the potential role of semaglutide and other GLP-1 receptor agonists in combating cognitive decline