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To counteract this and make the drug effective for a longer time, inhibitor molecules like that in PDB entry 3gss can be administered along with the drug to inhibit the action of the enzymes

To determine whether there might be a relationship between weight loss medication use immediately before or during pregnancy and various maternal and neonatal outcomes, we compared the rates of preterm delivery, high birth weight, neonatal intensive care unit (NICU) admission, and diagnoses of failure to thrive or congenital heart defect for babies born to mothers prescribed phentermine or a GLP-1 medication in the 90 days before pregnancy or during the first trimester to those with no documented weight loss medication exposure during pregnancy

10.1038/282260a0 43