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They're unstable molecules generated by things like UV radiation, pollution, and even normal metabolic processes
Shaking creates shearing forces that can denature the peptide
Due to their inhibitory effects on T cell activation and function, DPP-4 inhibitors (DPP-4i) have been successfully evaluated in vivo as immunosuppressive therapies using animal models of rheumatoid arthritis (RA), multiple sclerosis (MS), and transplantation
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