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A multicenter trial of 390 patients with diabetes mellitus receiving insulin therapy who were randomized to receive metformin, 850 mg three times daily, or placebo assessed the risk of vitamin B 12 deficiency and low vitamin B 12 levels over four years
When the results cannot be reproduced, the journal editors response is not immediately clear
Preferred for patients with MTHFR mutations (which are common in the general population) and for patients who want the most directly usable form
doi: 10.3390/nu11092232
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