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Although many of these studies have based their findings on peripheral markers of abnormal metabolism, many studies have documented some of these same abnormalities in the brain of individuals with ASD, including mitochondrial dysfunction and oxidative stress (30) and one study has demonstrated a link between oxidative stress, inflammation, and mitochondrial dysfunction in the brain of individuals with ASD (23)

[171] The review indicated that the severity of withdrawal symptoms is positively correlated with the age of the individual and the extent of their dependence