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Anti protease degradation Structural modification reduces its sensitivity to proteases, prolongs its half-life, and prolongs its duration of action

Collectively, this indicates a role for CNS GLP-1R populations to mediate food intake suppression by pharmacologic, and to a lesser degree physiologic, GLP-1R agonism

A second cohort of 209,649 patients with both IBD and T2D, of whom 38,567 had received a GLP-1 RA, was matched similarly, yielding 37,740 patients for analysis

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