tirzepatide.vs semaglutide Tirzepatide vs. Semaglutide: Which Weight Loss Drug Works Better? [May 2025 NEJM Study Explained] Tirzepatide vs. semaglutide: Study compares

In the analyses for PIONEER 2, 3 and 4, the results remained comparable to the base case analysis, with oral semaglutide 14 mg associated with a lower cost of control than all comparators for all four endpoints (Table 3)

As of now, BPC-157 has not received approval by the Food and Drug Administration (FDA) for clinical use

The takeaway for a clinic: the exposure is no longer hypothetical, and it is no longer confined to your supplier

Receptor-target and efficacy comparison: GLP-1 class agents | Agent | GLP-1 | GIP | Glucagon | Approval | Best trial weight loss | |---|---|---|---|---|---| | Liraglutide (Saxenda) | Yes | No | No | FDA-approved | 8.0% at 56 weeks (SCALE) | | Dulaglutide (Trulicity) | Yes | No | No | T2D only | 3.0 kg mean at 52 weeks | | Semaglutide (Wegovy) | Yes | No | No | FDA-approved | 14.9% at 68 weeks (STEP-1) | | Tirzepatide (Zepbound) | Yes | Yes | No | FDA-approved | 20.9% at 72 weeks (SURMOUNT-1) | | Retatrutide | Yes | Yes | Yes | Investigational | 24.2% at 48 weeks (Phase 2) | Liraglutide and Dulaglutide: Where They Fit Now Liraglutide (Saxenda, 3 mg once daily subcutaneous) was the first GLP-1 agonist approved specifically for obesity in the United States