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Comparative analysis between the mitoribosome and a bacterial homolog highlighted that these 2Fe-2S clusters are found where bacterial ribosomal RNA (rRNA) is typically engaged
SURMOUNT-MAINTAIN (Horn 2026, 112 weeks): continued top dose -21.9% vs 5 mg step-down -16.6% vs placebo -9.9%, rescue therapy 8/25/67%: Aronne JAMA 2024
Ambitious protocols integrate direct measurements: Electrophysiology LTP (Long-Term Potentiation) hippocampal on CA1 slices, gold standard of synaptic plasticity
(2) Anisimov VN, Khavinson VKh, Popovich IG, Zabezhinski MA, Alimova IN, Rosenfeld SV, Zavarzina NY, Semenchenko AV, Yashin AI
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