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And small peptide GLP-1 analogues have been demonstrated to cross BBB via peripheral administration, including LG, lixisenatide and exendin-4 ( Analyzing cerebrospinal fluid (CSF), ventricular fluid (VF), and postmortem brain tissue by means of multiplex bead-based ELISAs, the results of the experiment further suggested that there are fifteen cytokines whose levels are elevated in CSF and brain in the course of early-stage AD (84)
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Methods Tissue preparations All animal procedures were approved by the University of Cambridge Animal Welfare and Ethical Review Body and were conducted in accordance with the UK Animals (Scientific Procedures) Act 1986 Amendment Regulations (SI 2012/3039)
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