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Semaglutide and tirzepatide are the two FDA-approved medications in this class, and both have a substantial base of randomized trial evidence behind them, including weight reductions in the range of 1522% of body weight over roughly a year and a half in trial populations (NEJM)

The following groups have typically been excluded from clinical trials or would require careful specialist assessment, reflecting cautions seen across related approved medicines: A personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2): This is a theoretical concern that has led to exclusion from trials of GLP-1 receptor agonist therapies, based on animal data