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20 Post hoc analysis of the SUSTAIN trials comparing semaglutide with alternative GLP-1 agonists suggests superiority of semaglutide for weight loss and blood-glucose control, an effect that was independent of the presence of gastrointestinal adverse events
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In patients treated with semaglutide, median duration of nausea was 8 days, vomiting 2 days, diarrhoea 3 days, and constipation 47 days. Over the 68-week trial period nausea occurred in 43.9% of patients (16.1% placebo)
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