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As of late 2021, available evidence suggests first-line therapy with SGLT2 inhibitors may improve some outcomes, particularly in individuals with newly diagnosed diabetes and comorbid heart and kidney health concerns
Further, once patients achieve their desired weight, therapies that are safer, cheaper, and/or more convenient to administer may be needed to help sustain the durability of the response
Biochem Pharmacol 39: 225228
The immediate effect is often more about satiety (feeling full faster) than a total lack of appetite
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