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However, individual weight loss results can vary depending on factors such as diet, exercise, and how well the medication is tolerated

A severe caloric deficit triggers hypothalamic amenorrhea , where the brain temporarily shuts down ovulation to conserve energy for survival

A prescriber may consider: BMI and weight-related health risk previous weight-management attempts existing medical conditions current medicines pregnancy plans gastrointestinal health history of pancreatitis or gallbladder problems kidney and liver function diabetes treatment eating-disorder history ability to attend monitoring and follow-up NHS access is more restricted than general private eligibility

These actions are aimed to safeguard consumers from drugs for which the FDA cannot verify quality, safety, or efficacy, FDA Commissioner Martin Makary said in the announcement