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Membrane depolarization, triggered by a ligand-bound receptor, results in a spike of intracellular calcium (Ca 2+ ) which leads to the fusion of the endocrine granules with the lateral and the broader basal side, resulting in the discharge of a hormonal cargo in the capillaries of the mucosa

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We propose that sDPP4 acts as an activator of PAR2, since a sequence within the cysteine-rich region of DPP4 is highly homologous to the auto-activating tethered ligand of PAR2 ( Genetic alterations of DPP4 and predisposition to T2DM-associated diseases There are only few studies aiming to identify modifications in the DPP4 gene and their association with T2DM

Foundation (Daily if possible): Walking with stroller, 20-45 minutes