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The GI side effects that make some people miserable on higher doses are minimal or absent at lower doses

In the ATTAIN-MAINTAIN trial, orforglipron's profile was "consistent with previous orforglipron Phase 3 studies." The most common adverse events were gastrointestinal-related and were generally mild-to-moderate in severity, which is expected for the GLP-1 class

Patients are normally counseled about the potential bone loss that can come with weight loss and urged to take preventive steps like resistance training and using vitamin D and calcium supplements

Supplements work best when your body has the proper foundation