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Formulation patents, method-of-use patents, regulatory exclusivities, and pediatric extensions create a layered protection structure that routinely extends effective market exclusivity years beyond compound patent expiry
They also have two effects on the biliary system that, together, substantially increase the risk of gallstone disease: Rapid weight loss alters bile composition
Call your clinician promptly if you have: Nausea that does not improve or keeps returning Vomiting Inability to keep fluids down Signs of dehydration Severe abdominal pain Pain that radiates to the back Significant bloating or abdominal swelling Fever Yellowing of the skin or eyes Dark urine with abdominal pain Blood in vomit or stool Dizziness or fainting Very low food intake for more than a short period Symptoms after a recent dose increase Nausea that prevents work, sleep, hydration, or medication adherence Zepbound prescribing information tells patients to stop using the medication and call a healthcare provider right away for severe stomach pain that will not go away, with or without nausea or vomiting
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